EC genomic reprogramming in different organs and diseases share both similarities and organ-specific disease-dependent differences. We have been developing novel models for quantifying phenotypic traits in angiogenesis in EC in mouse retina (diabetic retinopathy), lung and kidney (diabetes), and sharpening the analysis of genomic, proteomic, metabolomic and imaging data, to apply to comparative study of angiogenesis and EC reprogramming. One set of tools provide visual analytics and quantitative measures of dynamics in mRNA expression in EC wild-type and various mutants.
We are interested in collaboration with biologists and clinical researchers who would be interested in development of advanced and accurate models of EC and angiogenesis based on their lab genotypic and phenotypic data. The specific requirement for full applicability of methods and models is to have time-stamped whole genome mRNA and/or time-lapse image data. Other data could be also analyzed, depending on specific circumstances and the sufficiency of the data.