role of cam kinase II in hepatic stellate cell functionListed By : Jonathan A. Dranoff
University of Arkansas for the Medical Sciences
CategoryGenePathwayDiseaseMember Organization
Research projectCAMK2G - calcium/calmodulin-dependent protein kinase (CaM kinase) II gammaExtracellular matrixGastroenterologyYale
Recently we demonstrated that intracellular calcium regulates proliferation of hepatic stellate cells via CaMK II. We now have preliminary evidence that CaMK II regulates matrix release and myofibroblastic differentiation of hepatic stellate cells and thus is an attractive target in liver fibrosis. We think that the relevant CaMK II isoforms are gamma and delta, since these seem to be the only isoforms expressed by HSC.

We are looking for collaborators on this project, especially in the development of animal models of disease relevant to our preliminary discoveries.
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